Do 0-10 numeric rating scores translate into clinically meaningful pain measures for children?

Background: Self-reported pain scores are used widely in clinical and research settings, yet little is known about their interpretability in children. In this prospective, observational study we evaluated the relationship between 0 to 10 numerical rating scale (NRS) pain scores and other self-reported, clinically meaningful outcomes, including perceived need for medicine (PNM), pain relief (PR), and perceived satisfaction (PS) with treatment in children postoperatively.

Methods: This study included children ages 7 to 16 years undergoing surgery associated with postoperative pain.

Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock.

Objectives: To explore how the potent vasoconstrictive features of vasopressin impact the rate of cardiovascular collapse and metabolic derangements associated with prolonged hemorrhagic shock.

Design: A prospective randomized trial.

Setting: University hospital-based animal laboratory.