A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain.

Background: To understand the role of microglia in brain function and development, methods have emerged to deplete microglia throughout the brain. Liposome-encapsulated clodronate (LEC) can be infused into the brain to deplete microglia in a brain-region and time-specific manner.

New Method: This study validates methodology to deplete microglia in the rat dorsal hippocampus (dHP) during a specific period of juvenile development.

An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach.

Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal Zika virus (ZIKV) infection in humans has been limited. Our lab has developed a rat model of maternal ZIKV infection with associated vertical transmission to the fetus that results in significant brain malformations in the neonatal offspring. Here, we use this model in conjunction with longitudinal magnetic resonance imaging (MRI) to expand our understanding of the long-term neurological consequences of prenatal ZIKV infection in order to identify characteristic neurodevelopmental changes and track them across time.

Selective Atrophy of the Vastus Medialis: Does It Exist in Women With Nontraumatic Patellofemoral Pain?

Background: A commonly cited theory related to the pathomechanics of patellofemoral pain (PFP) states that atrophy of the vastus medialis (VM) muscle leads to lateral tracking of the patella. However, isolated atrophy of the VM or atrophy of the quadriceps muscle group as a whole, has not been consistently reported in this population.

Purpose: To compare individual and total quadriceps muscle volumes between women with nontraumatic PFP and women without PFP as measured on magnetic resonance imaging scans.

An IL-6 receptor antagonist attenuates postpartum anhedonia, but has no effect on anhedonia precipitated by subchronic stress in female rats.

Rationale: Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the function of the peripheral immune system is significantly altered during pregnancy in order to protect the developing fetus from being rejected by the maternal immune system (Fallon et al.

Mercury Concentrations in Feathers of Adult and Nestling Osprey (Pandion haliaetus) from Coastal and Freshwater Environments of Florida.

We determined mercury (Hg) concentrations in feathers of osprey (Pandion haliaetus), both nestlings (n = 95) and adults (n = 110), across peninsular Florida and the Florida Keys during February-August 2014. Feathers plucked from nestlings, aged 3-7 weeks, contained Hg concentrations that ranged from 0.338 to 45.

Fixation of supracondylar femoral fractures following total knee arthroplasty: is there any difference comparing angular stable plate fixation versus rigid interlocking nail fixation?

Introduction: Literature does not provide any reliable comparison between angular stable plate fixation and rigid nail fixation for stabilization of supracondylar periprosthetic femoral fractures. Thus, the purpose of this study was to compare these two implants in clinical practice relating to fracture healing, functional results and treatment-related complications.

Patients And Methods: In this retrospective study (level IV), clinical and radiographic records of 86 patients (62 female and 24 male, average age: 75.

Mild executive dysfunctions in undergraduates are related to recollecting words never presented.

The aim of this study was to explore whether individual differences in executive function in undergraduate students (n = 72) contribute to false recall and recognition as obtained with the Deese/Roediger-McDermott (DRM) paradigm. Participants were subjected to the DRM paradigm and also were given a test designed to assess executive function--the Random Number Generation task (RNG). A relationship was found between heightened seriation on the RNG (indicating a deficiency in the ability to inhibit cognitive schemes) and false recognition of non-presented, critical lure words in the DRM paradigm.