Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice.

Sickle cell disease (SCD) is an inherited blood disorder caused by a mutation in the HBB gene leading to hemoglobin S production and polymerization under hypoxia conditions leading to vaso-occlusion, chronic hemolysis, and progressive organ damage. This disease affects ~100,000 people in the United States and millions worldwide. An effective therapy for SCD is fetal hemoglobin (HbF) induction by pharmacologic agents such as hydroxyurea, the only Food and Drug Administration-approved drug for this purpose.

Whitefly feeding behavior and retention of a foregut-borne crinivirus exposed to artificial diets with different pH values.

Transmission of plant viruses by phytophagous hemipteran insects encompasses complex interactions underlying a continuum of processes involved in virus acquisition, retention and inoculation combined with vector feeding behavior. Here, we investigated the effects of dietary pH on whitefly (Bemisia tabaci) feeding behavior and release of Lettuce infectious yellows virus (LIYV) virions retained in the vector's foregut. Electrical penetration graph analysis revealed that variables associated with whitefly probing and ingestion did not differ significantly in pH (4, 7.

Adult zebrafish hearts efficiently compensate for excessive forced overload cardiac stress with hyperplastic cardiomegaly.

Although human cardiomyocytes (CMs) are capable of some cell division, this response is neither sufficient to repair damaged cardiac tissue nor efficient to compensate for pathological stress. Danio rerio (zebrafish) CMs have been shown to have high proliferative capability to completely repair hearts after injury; however, no reports have focused on their physiological and cellular response to cardiac overload stress. We hypothesized that forced excessive long-term cardiac overload stress would elicit a proliferative response similar to regenerative cardiac repair in zebrafish.