Scheduling surgical success: Early minimally invasive surgery rotations as a predictor of ABSITE performance.

Introduction: The American Board of Surgery In-Training Examination (ABSITE®) serves as a benchmark for assessing resident knowledge and comprehension in surgery training programs. While previous studies have examined factors such as USMLE Step 1 and Step 2 performance in ABSITE® preparation, the impact of rotational schedule on ABSITE® performance remains underexplored.

Methods: We retrospectively investigated the independent influence of rotational schedule on ABSITE® performance among interns at a single academic institution over an 11 year period.

Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (PDC) deficiency: Impact on PDC-E1 structure and function.

Pyruvate dehydrogenase complex deficiency is a major cause of primary lactic acidemia resulting in high morbidity and mortality, with limited therapeutic options. PDHA1 mutations are responsible for >82% of cases. The E1 component of PDC is a symmetric dimer of heterodimers (αβ/α'β') encoded by PDHA1 and PDHB.

Acute sleep disruption- and high-fat diet-induced hypothalamic inflammation are not related to glucose tolerance in mice.

Chronic insufficient sleep is a major societal problem and is associated with increased risk of metabolic disease. Hypothalamic inflammation contributes to hyperphagia and weight gain in diet-induced obesity, but insufficient sleep-induced neuroinflammation has yet to be examined in relation to metabolic function. We therefore fragmented sleep of adult male C57BL/6J mice for 18 h daily for 9 days to determine whether sleep disruption elicits inflammatory responses in brain regions that regulate energy balance and whether this relates to glycemic control.