Publications by authors named "Nicole Gonzalez-Nava"
An evolutionarily acquired microRNA shapes development of mammalian cortical projections.
Proc Natl Acad Sci U S A
November 2020
Article Synopsis
- The corticospinal tract and corpus callosum are specialized structures in mammals that contribute to advanced motor and cognitive abilities.
- Researchers have identified 17 specific microRNAs (miRNAs) that are enriched in corticospinal motor neurons, 15 of which originate from a unique genomic cluster found only in placental mammals.
- One particular miRNA, miR-409-3p, plays a crucial role in determining the identity of corticospinal motor neurons by inhibiting a gene involved in developing another type of neuron, showcasing how evolution has influenced neuronal diversity in mammals.