Publications by authors named "Nicole Giunio-Zorkin"
Background: Given altered pharmacokinetics in people with cystic fibrosis (pwCF), there is debate regarding optimal strategies for therapeutic drug monitoring (TDM) for aminoglycosides and vancomycin administered intravenously.
Objectives: To determine the TDM strategy for IV aminoglycosides and IV vancomycin associated with optimal clinical outcomes in pwCF.
Data Sources: Several databases (MEDLINE, Embase, CINAHL, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.
Real-Life Frequency of New-Onset Thrombocytopenia during Linezolid Treatment.
Can J Hosp Pharm
April 2018
Article Synopsis
- - The study investigated the occurrence of new-onset thrombocytopenia (low platelet count) in patients treated with linezolid, finding it affected 17.6% of the patients studied.
- - Researchers analyzed data from 102 patients who received linezolid for at least 5 days, highlighting key risk factors such as longer duration of therapy, renal impairment, and concurrent use of unfractionated heparin.
- - The findings suggest that the likelihood of developing thrombocytopenia increases with prolonged treatment and certain patient characteristics, emphasizing the need for monitoring in those receiving linezolid.