Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs.

Objective: To evaluate the cardiopulmonary and sedative effects of the peripheral α(2)-adrenoceptor antagonist MK 0467 when administered IM or IV concurrently with medetomidine in dogs.

Animals: 8 adult dogs.

Procedures: Dogs received 20 μg of medetomidine/kg, IM, alone or concurrently with MK 0467 (0.