Publications by authors named "Nicole Darbour"
Article Synopsis
- The study analyzed the phytochemical properties of Marrubium deserti, resulting in the discovery of new labdane diterpenes named marrulibacetal A and desertine, along with various known compounds.
- A total of 13 phenolic compounds and terpenoids were isolated, including several derivatives of apigenin and phenylethanoid glucosides.
- The antioxidant activities of some compounds were tested with promising results, showing superior capacity compared to trolox, and exhibited potential genotoxic and antigenotoxic effects on Escherichia coli.
Bio-guided fractionation of the roots of Paris polyphylla (Trilliaceae), based on inhibition of P-glycoprotein-mediated daunorubicin efflux in K562/R7 cell line, led to isolation and identification of the three saponins 3-O-Rha(1-->2)[Ara(1-->4)]Glc-pennogenine, gracillin and polyphyllin D, and the two ecdysteroids 20-hydroxyecdysone and pinnatasterone. These compounds were tested for multidrug reversion on P-glycoprotein (ABCB1) with both drug-selected and transfected cell lines, and also on Breast Cancer Resistance Protein (BCRP/ABCG2). By contrast to a weak efficiency on BCRP, the three saponins displayed significant effects as inhibitors of P-glycoprotein-mediated drug efflux.
View Article and Find Full Text PDFFrom the dichloromethane extract of aerial parts of Ferula vesceritensis (Apiaceae), 11 sesquiterpene derivatives were isolated. Among them five were compounds designated as 10-hydroxylancerodiol-6-anisate, 2,10-diacetyl-8-hydroxyferutriol-6-anisate, 10-hydroxylancerodiol-6-benzoate, vesceritenone and epoxy-vesceritenol. The six known compounds were identified as feselol, farnesiferol A, lapidol, 2-acetyl-jaeschkeanadiol-6-anisate, lasidiol-10-anisate and 10-oxo-jaesckeanadiol-6-anisate.
View Article and Find Full Text PDFArticle Synopsis
- A new isoflavone called 5,7-dihydroxy-4'-methoxy-3'-(2,3-dihydroxy-3-methylbutyl)isoflavone was discovered in the stem bark of Ficus nymphaefolia Mill.
- Eight known isoflavones were also identified, including genistein and erycibenin A.
- The structures of these compounds were determined through advanced spectral analysis techniques, specifically 1D and 2D NMR experiments.