The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection.

Dysregulated host immune responses contribute to disease severity and worsened prognosis in COVID-19 infection and the underlying mechanisms are not fully understood. In this study, we observed that IL-33, a damage-associated molecular pattern molecule, is significantly increased in COVID-19 patients and in SARS-CoV-2-infected mice. Using IL-33 mice, we demonstrated that IL-33 deficiency resulted in significant decreases in bodyweight loss, tissue viral burdens, and lung pathology.

A case of endogenous endophthalmitis after a mild dental infection.

Endophthalmitis is a rare but severe vision threatening disease that most often occurs in patients with a recent history of ophthalmic surgery or penetrating trauma to the eye. Often these patients have underlying risk factors or are immunosuppressed. We present a case of endogenous endophthalmitis in an otherwise healthy male after a tooth extraction.