Empiric Antimicrobial Treatment of Anastomotic Leakage after Esophageal Resection: The most commonly used antimicrobial regimens in The Netherlands and an antimicrobial treatment recommendation based on a single center population.

Introduction: The development of anastomotic leakage (AL) after esophagectomy is a severe complication, often leading to mediastinitis and systemic infections. Effective empiric antimicrobial therapy is crucial, but there is no consensus on the optimal regimen. This study aims to document antimicrobial regimens used in the Netherlands and to evaluate culture results from AL after esophagectomy at our center.