Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration.

Background: The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention.

Methods: We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours after discharge from anesthetic care (transfer from the postanesthesia care unit or transfer from the operating room to postoperative areas) between July 1, 2008, and June 30, 2010. Patients were matched to 2 control subjects based on age, sex, and exact type of procedure performed during the same year.

Pharmacogenetic workup of perioperative serotonin syndrome.

Serotonin syndrome is gaining attention in perioperative and chronic pain settings due to the growing prevalence of multimodal therapies that increase serotonin levels and thereby heighten patient risk. A patient's genetic make-up may further increase the risk of serotonin syndrome. A case of serotonin syndrome on emergence after general anesthesia is presented.

Analgesia after Cesarean delivery: a retrospective comparison of intrathecal hydromorphone and morphine.

Study Objective: To compare analgesia and opioid-related side effects of intrathecal morphine and intrathecal hydromorphone after elective Cesarean delivery.

Design: Retrospective, comparative study.

Setting: Labor and delivery unit of an academic hospital.