Time to diagnosis of brain tumors in children: a single-centre experience.

Background: The aim of the study was to analyze the pre-diagnostic symptomatic interval (PSI) of children with brain tumors with regard to the parental and doctor's delay and the clinical symptoms.

Methods: A retrospective review of all children with brain tumors diagnosed in a single centre over a period of 11 years was carried out.

Results: Seventy-nine patients (35 boys, 44 girls), with a mean age of 9.

Neuroendocrine tumors of the appendix in children and adolescents.

Background: Neuroendocrine tumors (NET) of the appendix in children and adolescents are rare and mostly detected postoperatively by a histopathological examination. Since the malignant potential of these tumors remains unclear, therapeutic recommendations are not evidence based. The Society of Pediatric Oncology and Hematology (GPOH) has prospectively registered and followed children with appendical NET since 1997 (GPOH-MET trial).

Sensitivity of fine-needle biopsy in detecting pediatric differentiated thyroid carcinoma.

Background: Differentiated thyroid carcinomas (DTC) are uncommon in children. Since the frequency of malignancy is assumed to be high in pediatric symptomatic thyroid nodules, carcinomas should be ruled out reliably. The objective of this study was to assess the sensitivity of fine-needle biopsy (FNB) in diagnosing children with DTC.