Examination of ELN as a candidate gene in the Utah intracranial aneurysm pedigrees.

Background And Purpose: A study of intracranial aneurysm (IA) sibpairs suggested association of an ELN haplotype with IA risk. Subsequent linkage analysis of the ELN region on chromosome 7q11 in high-risk Utah IA pedigrees significantly confirmed linkage between IA and the ELN region.

Methods: We have investigated the ELN gene as a potential candidate gene for IA in Utah pedigrees.