Future Innovations in Viral Immune Surveillance: A Novel Place for Bioinformation and Artificial Intelligence in the Administration of Health Care.

Novel developments in bioinformation, bioinformatics and biostatistics, including artificial intelligence (AI), play a timely and critical role in translational care. Case in point, the extent to which viral immune surveillance is regulated by immune cells and soluble factors, and by non-immune factors informs the administration of health care. The events by which health is regained following viral infection is an allostatic process, which can be modeled using Hilbert's and Volterra's mathematical biology criteria, and biostatistical methodologies such as linear multiple regression.

Quantitative Consensus in Systematic Reviews: Current and Future Challenges in Translational Science.

Translational science conceptualizes healthcare as a concerted set of processes that integrate research findings from the bench to the bedside. This model of healthcare is effectiveness-focused, patient-centered, and evidence-based, and yields evidence-based revisions of practice-based guidelines, which emerge from research synthesis protocols in comparative effectiveness research that are disseminated in systematic reviews. Systematic reviews produce qualitative and quantitative consensi of the best available evidence.

Telenursing: Bioinformation Cornerstone in Healthcare for the 21st Century.

Bioinformation is at the very core of 21st-century healthcare. Telehealth consists of the range of healthcare-related services delivered through bioinformation-aided telecommunications across health-related disciplines, including nursing. Whereas it is clear that bedside patient-centered nursing can never be replaced, recent developments in bioinformation-aided telenursing will undoubtedly contribute to improving healthcare effectiveness and efficacy.

Clinical Immunology of Cholera - Current Trends and Directions for Future Advancement.

Cholera remains a feared, aggressive, infectious and lethal disease today, despite several decades of intense research, concerted public health modalities designed to prevent, and to control outbreaks, availability of efficacious vaccines aimed at containing its contagious spread, and effective patient-centered medical interventions for reducing morbidity and mortality. Despite these advances, cholera still strikes communities around the world, especially in countries and regions of the globe where medical and nursing care cannot be as effectively proffered to the population at risk as in First World economies. Case in point, the number of suspected cholera cases that currently afflicts Yemen escalates at an "unprecedented rate", according to the World Health Organization.

Lubricin: A Principal Modulator of the Psychoneuroendocrine - Osteoimmune Interactome - Implications for Novel Treatments of Osteoarthritic Pathologies.

Lubricin is a synovial glycoprotein that contributes to joint lubrication. We propose the hypothesis that lubricin is a key modulator of the psychoneuroendocrine-osteoimmune interactome, with important clinical relevance for osteoarthritic pathologies. We consider a variety of neuroendocrine-immune factors, including inflammatory cytokines and chemokines that may contribute to the modulation of lubricin in rheumatic complications.