The development of autonomic cardiovascular control is altered by preterm birth.

Objectives: Autonomic dysfunction, either sympathetic or parasympathetic, may explain the increased incidence of Sudden Infant Death Syndrome (SIDS) among preterm infants, as well as their subsequent heightened risk of hypertension in adulthood. As little is known about the development of autonomic function in preterm infants, we contrasted autonomic cardiovascular control across the first 6months after term-corrected age (CA) in preterm and term infants.

Study Design: Preterm (n=25) and age matched term infants (n=31) were studied at 2-4weeks, 2-3months and 5-6months CA using daytime polysomnography.

Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants.

Objective: Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest.

Methods: Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography.

Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep prone.

Objective: Prone sleeping is a major risk factor for the sudden infant death syndrome and is associated with lower blood pressure and impaired arousability from sleep, both of which may be signs of cerebral hypoxia. However, the impact of sleep position on cerebral oxygenation during infancy remains unknown. We assessed the effects of sleeping position, sleep state, and postnatal age on cerebral oxygenation by measuring tissue oxygenation index (TOI) during the first 6 months of infancy.

Cardiovascular control during sleep in infants: Implications for Sudden Infant Death Syndrome.

In infants the cardiorespiratory system undergoes significant functional maturation after birth and these changes are sleep-state dependent. Given the immaturity of these systems it is not surprising that infants are at risk of cardiorespiratory instability, especially during sleep. A failure of cardiovascular control mechanisms in particular is believed to play a role in the final event of Sudden Infant Death Syndrome (SIDS).

Delayed blood pressure recovery after head-up tilting during sleep in preterm infants.

Dramatic changes in cardiovascular control occur in sleep during infancy, when sleep time is at a lifetime maximum. In infants born preterm there are significant cardiovascular complications later in life, and also an increased risk for sudden infant death syndrome (SIDS), possibly a result of inadequate compensation to a cardiorespiratory challenge in sleep. We aimed to examine the consequences of preterm birth on heart rate (HR) and blood pressure (BP) responses to head-up tilting (HUT) during sleep in infants.

Blood pressure and heart rate patterns during sleep are altered in preterm-born infants: implications for sudden infant death syndrome.

Objective: Preterm infants are at an increased risk of sudden infant death syndrome, which may result from immature autonomic control of heart rate and blood pressure. Previous studies have demonstrated that preterm infants have altered heart rate and blood pressure control at term-equivalent age; however, little information is available beyond this age. The aim of this study was to determine the effect of preterm birth on heart rate and blood pressure control over the first 6 months of life after reaching term-equivalent age, including the age at which sudden infant death syndrome risk is increased, to understand the pathogenesis of sudden infant death syndrome.