Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Background: Bisphosphonate drugs can be used to prevent and treat osteoporosis and to reduce symptoms and complications of metastatic bone disease; however, they are associated with a rare but serious adverse event: osteonecrosis of the maxillary and mandibular bones. This condition is called bisphosphonate-related osteonecrosis of the jaw or BRONJ. BRONJ is diagnosed when people who are taking, or have previously taken, bisphosphonates have exposed bone in the jaw area for more than eight weeks in the absence of radiation treatment.

Antibiotic duration for treating uncomplicated, symptomatic lower urinary tract infections in elderly women.

Background: Urinary tract infections (UTI) are common in elderly patients. Authors of non systematic literature reviews often recommend longer treatment durations (7 to 14 days) for older women, but the evidence for such recommendations is unclear.

Objectives: To determine the optimal duration of antibiotic treatment for uncomplicated symptomatic lower UTI in elderly women.