Publications by authors named "Nicole Aguirre"

Background: Appendiceal epithelial tumors are rare and encompass a broad set of adenocarcinoma histologies, including mucinous (mAC), colonic-type (cAC), and goblet cell (GCA) adenocarcinomas. It has previously been reported that nodal disease predicted recurrence in patients with nonmetastatic appendiceal adenocarcinomas, supporting diagnostic laparoscopy with right hemicolectomy for staging and assessment for risk of recurrence. In this update, we sought to identify predictors of nodal disease on initial diagnostic pathology in nonmetastatic adenocarcinomas.

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Article Synopsis
  • Fluorescence-guided surgery relies on the ability of dyes to highlight tumor tissue compared to healthy tissue, and the dye CJ215 shows promise for this application due to its favorable optical properties.
  • CJ215, a carbocyanine dye that is cleared by the kidneys, enables effective tumor detection and evaluation of wound healing within a day of intravenous injection, with minimal presence in healthy organs.
  • In studies involving various cancer types, CJ215 provided significantly high contrast ratios for tumors compared to muscle and liver, and it also offered non-contact monitoring of wounds using shortwave infrared fluorescence imaging.
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Purpose: Well-differentiated papillary peritoneal mesothelial tumors (WDPMTs) are understudied and discrete from peritoneal mesotheliomas (PMs). We report clinicopathologic characteristics and outcomes of a large prospective WDPMT cohort.

Methods: Patients with WDPMT identified between August 2007 and December 2020 were followed through January 2023.

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Article Synopsis
  • Fluorescence guided surgery (FGS) uses special dyes for real-time identification of tumors, improving surgical outcomes by distinguishing tumors from healthy tissue.
  • A specific dye, CJ215, targets apoptosis (cell death) and has been validated in various cancer models, showing high contrast imaging effectiveness in near infrared and shortwave infrared settings.
  • CJ215 allows for detailed tumor visualization with minimal impact on healthy organs and can be used for tumor assessment, surgical guidance, and post-operative wound monitoring, integrating into current clinical practices.
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Background Ond Objectives: Complete cytoreductive surgery (CRS) may prolong survival for selected patients with peritoneal carcinomatosis from colorectal cancer (CRC). However, there is a paucity of data on outcomes following incomplete procedures.

Methods: Patients with incomplete CRS for well-differentiated (WD) and moderate/poorly-differentiated (M/PD) appendiceal cancer, right and left CRC were identified at a single tertiary center (2008-2021).

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Type II diabetes mellitus (DM2) is a worldwide disease with an important economic and health impact. Currently, depression, anxiety and stress are common disorders among diabetic populations but their respective prevalence may well be underestimated. So far, Latin American countries have only reported limited information about the impact of mental diseases on DM2 outpatients.

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With 1 in 3 women affected, accounting for one billion women worldwide, Violence Against Women (VAW) constitutes one of the widest reaching human rights violations globally. Although the forms they take may vary, these abuses are not confined to a single social class, geographic region, or culture. Existing studies have yet to describe the full burden of abuse that asylum-seeking women endure throughout their lifetimes.

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Estimates by the World Health Organization indicate that 1 in 3 women-more than one billion people worldwide-have experienced some form of Gender-Based Violence (GBV). Violence Against Women (VAW) is a prominent subset of GBV, defined by the United Nations as any act "that results in, or is likely to result in, physical, sexual, or mental harm or suffering to women, including threats of such acts, coercion or arbitrary deprivation of liberty, whether occurring in public or in private life." VAW can include verbal harassment, physical abuse, sexual abuse, honor killing, and femicide and can occur at the hands of individuals, institutions, or states.

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