Publications by authors named "Nicole A Losurdo"

Article Synopsis
  • Researchers used RNA interference (RNAi) to identify genes important for brain growth, focusing on an anti-lipogenic gene and its effects during brain development.
  • They discovered that knocking down this gene in neuronal stem cells reduced brain lobe volume but the same effect wasn’t seen in a newly generated mutant fly.
  • The study concludes that the anti-lipogenic gene does not appear to play a significant role in brain growth, despite affecting fat content in other body parts.
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Dopamine has a significant role in motor and cognitive function. The dopaminergic pathways originating from the midbrain have received the most attention; however, the relevance of the cerebellar dopaminergic system is largely undiscovered. Here, we show that the major cerebellar astrocyte type Bergmann glial cells express D1 receptors.

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Case studies and student-led learning activities are both effective active learning methods for increasing student engagement, promoting student learning, and improving student performance. Here, we describe combining these instructional methods to use student-created case studies as assessment for an online neurovirology module in a neuroanatomy and physiology course. First, students learned about neurovirology in a flipped classroom format using free, open-access virology resources.

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AbstractFollowing traumatic spinal cord injury, most mammalian species are unable to achieve substantial neuronal regeneration and often experience loss of locomotor function. In contrast, larval sea lampreys () spontaneously recover normal swimming behaviors by 10-12 weeks post-injury, which is supported by robust regeneration of spinal axons. While recovery of swimming behavior is well established, the lamprey's ability to recover more complex behaviors, such as burrowing, is unknown.

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