Publications by authors named "Nicole A Beckley"
Inhibition of RTK pathways in cancer triggers an adaptive response that promotes therapeutic resistance. Because the adaptive response is multifaceted, the optimal approach to blunting it remains undetermined. TNF upregulation is a biologically significant response to EGFR inhibition in NSCLC.
View Article and Find Full Text PDFVentral tegmental area (VTA) neurons receive glutamatergic and/or GABAergic input from other local neurons within the VTA. Nicotinic acetylcholine receptor (nAChR) activity is capable of modulating such intra-VTA transmission, but the mechanisms are unclear. Here, we isolated monosynaptic glutamate or GABA transmission from mouse medial VTA (mVTA) to lateral VTA (latVTA) using pharmacology and optogenetics, and we studied the ability of nicotine to modulate these modes of transmission.
View Article and Find Full Text PDFArticle Synopsis
- Antagonism of nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb) and interpeduncular nucleus (IPN) in mice suggests that nicotine dependence may be linked to enhanced nicotinic signaling, leading to withdrawal-like behaviors.
- Chronic nicotine exposure was shown to significantly boost nAChR function in MHb neurons, enhancing their action potential firing and glutamate release, indicating changes in brain circuitry related to addiction.
- The study revealed that chronic nicotine also increases nAChR function in IPN neurons, indicating that prolonged nicotine use alters cholinergic signaling in critical brain areas, which may offer insights