Publications by authors named "Nicolas Zeippen"
Trypanosoma cruzi, the protozoan agent of Chagas disease in the Americas, is comprised of six genetic lineages (TcI-TcVI) and a possible seventh (TcBat, related to TcI). Identification of T. cruzi lineages infecting reservoir mammalian species is fundamental to resolving transmission cycles.
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- Intracellular bacteria like Brucella abortus must manage DNA damage caused by alkylating agents when they infect host cells, particularly in macrophages.
- The study shows that B. abortus relies on specific genes for DNA repair, highlighting the role of both direct and base-excision repair mechanisms during this stress.
- Notably, the gene ogt, essential for DNA repair, is regulated by the transcription factor GcrA, indicating unique features of DNA repair in B. abortus compared to well-studied bacteria like Escherichia coli.
Background: Trypanosoma cruzi, the protozoan agent of Chagas disease, is comprised of at least 6 genetic lineages (TcI-TcVI). Their geographical distribution, clinical associations and reservoir hosts are not fully elucidated, as genotyping is hampered due to the difficulty in isolating representative populations of organisms. Lineage-specific serological techniques may address these issues.
View Article and Find Full Text PDFBackground: Trypanosoma cruzi causes Chagas disease in the Americas. The outcome of infection ranges from lifelong asymptomatic status to severe disease. Relationship between T.
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