Publications by authors named "Nicolas Yannuzzi"
Stickler syndrome, a rare connective tissue disorder, presents with a broad spectrum of ocular manifestations, including myopia, vitreoretinal degeneration, glaucoma, and retinal detachment. While extensive data exists on the treatment outcomes of retinal detachment repair in Stickler syndrome, the potential risks associated with acute postoperative intraocular pressure elevation remain underexplored. We report the case of a 10-year-old boy with Stickler syndrome who underwent scleral buckling surgery and subsequently experienced ocular hypertension.
View Article and Find Full Text PDFTo assess current trends in vitreoretinal surgical fellowship training for placement of secondary intraocular lenses (IOLs). : A cross-sectional survey was administered to vitreoretinal surgical fellowship graduates who completed their program between 2019 and 2023. Completed responses were obtained from 70 (22.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of the Generative Pre-trained Transformer 4 with vision in diagnosing vitreoretinal diseases in real-world settings at Bascom Palmer Eye Clinic, analyzing retrospective patient data from 2010 to 2023.
- Results showed low diagnostic accuracy, with 13.7% for open-ended questions and 31.3% for multiple-choice questions, while ICD-10 coding accuracy was similarly low, particularly struggling with complex cases.
- The findings suggest that while the model has potential in clinical care, particularly for standardized questions, it has significant limitations in handling more complex medical inquiries.
Article Synopsis
- The study looked at 20 eyes from 14 patients who had surgery due to problems caused by two eye diseases: sickle cell retinopathy and diabetic retinopathy.
- Most of the surgeries were done because of serious issues like retinal detachments or bleeding inside the eye.
- The results showed that the surgery didn't really improve vision for most patients, and only some had successful fixes to their retinal problems.
Purpose Of Review: We describe the history, utilization, and series results of panretinal photocoagulation (PRP) and ranibizumab and provide an analysis of PRP and ranibizumab usage before versus after the publication of the 2-year and 5-year results of the Diabetic Retinopathy Clinical Research Network (DRCR.net) Protocol S trial.
Recent Findings: Number of ranibizumabs performed began to increase and number of PRPs performed began to decrease in 2016.
Topic: This systematic review and meta-analysis investigates the efficacy and safety of anti-VEGF injections compared with surgical intervention in improving visual acuity (VA) and reducing complications for patients with submacular hemorrhage (SMH) due to neovascular age-related macular degeneration (AMD).
Clinical Relevance: Determining the optimal intervention for SMH in AMD is crucial for patient care.
Methods: We included studies on anti-VEGF injections or surgical interventions for SMH in AMD from 7 databases, searched up to May 2024.
Purpose: To assess ocular pain in patients undergoing multiple intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) who have previous factors that may influence pain sensitivity.
Methodology: This is a prospective, observational, case series study involving patients who underwent multiple (≥3) pro re nata intravitreal injections of ranibizumab or aflibercept to treat any cause of chorioretinal vascular disease. Ocular pain was assessed by the numerical analog scale during intravitreal injection.
Article Synopsis
- The study assessed the cost effectiveness of treating geographic atrophy (GA) using two different medications: intravitreal avacincaptad pegol (ACP) and pegcetacoplan (PEG).
- Cost analyses were conducted using 2022 Medicare reimbursement data, focusing on both hospital and non-hospital settings in Miami, with treatment outcomes drawn from previous clinical trials.
- Results showed that while ACP treatment had varying costs based on treatment frequency, it was generally less cost effective for extrafoveal lesions compared to PEG, with EOM (every other month) treatment being more cost effective than EM (every month) for ACP.
Faricimab in Previously Treated Eyes With Neovascular Age-Related Macular Degeneration: An Assessment of Durability and Treatment Outcomes.
Ophthalmic Surg Lasers Imaging Retina
September 2024
Background And Objective: This study evaluated the efficacy and durability of faricimab in patients with neovascular age-related macular degeneration (nAMD) who were previously treated with anti-vascular endothelial growth factor (anti-VEGF) agents.
Patients And Methods: This retrospective case series was conducted at a single tertiary center in the United States. It focused on nAMD patients who transitioned to faricimab after initial anti-VEGF therapy, with a follow-up period of at least 9 months.
Purpose Of Review: We describe the history and series results of pneumatic retinopexy (PnR)and provide an analysis of PnR utilization after publication of results of pneumatic retinopexy versus vitrectomy for the management of primary rhegmatogenous retinal detachment outcomes randomized trial (PIVOT).
Recent Findings: No significant trends were found for average number of services ( P = 0.153) of PnR after the publication of PIVOT results.
Purpose: To sequence, identify, and perform phylogenetic and recombination analysis on three clinical adenovirus samples taken from the vitreous humor at the Bascom Palmer Eye Institute.
Methods: The PacBio Sequel II was used to sequence the genomes of the three clinical adenovirus isolates. To identify the isolates, a full genome-based multiple sequence alignment (MSA) of 722 mastadenoviruses was generated using multiple alignment using fast Fourier transform (MAFFT).
Purpose: To evaluate features of infectious panuveitis associated with multiple pathogens detected by ocular fluid sampling.
Methods: Single-center, retrospective, consecutive case series of patients with aqueous/vitreous polymerase chain reaction testing with >1 positive result in a single sample from 2001 to 2021.
Results: Of 1,588 polymerase chain reaction samples, 28 (1.
Purpose: To describe the clinical characteristics, multimodal imaging features, and anatomic basis of a distinctive pattern of deep retinal hemorrhages located in the central fovea, a presentation referred to as "central bouquet hemorrhage."
Methods: Retrospective, observational, multicenter case series of eyes with central bouquet hemorrhage. Multimodal imaging features were reviewed and analyzed.
Ophthalmic surgeons are at an increased risk for musculoskeletal disorders resulting from ophthalmology-specific routines and equipment, which have become widely associated with poor posture. The purpose of this study was to observe the effect that a commercially available posture trainer, Upright Go, can have on the improvement of posture of ophthalmic surgeons. Eight ophthalmologists-in-training were studied over a period of 4 weeks during their surgical rotations between September 2020 and June 2021.
View Article and Find Full Text PDFClinical Outcome of Cystoid Macular Edema in Silicone Oil-Filled Eyes.
J Vitreoretin Dis
September 2023
To investigate the clinical outcome of cystoid macular edema (CME) in eyes undergoing silicone oil (SO) tamponade with subsequent SO removal (SOR). A retrospective case series of adult patients with CME treated with SO tamponade and SOR was conducted between January 2015 and January 2021. Exclusion criteria included eyes with a prior SO tamponade, those that did not undergo SOR, or those with infectious/inflammatory diagnoses.
View Article and Find Full Text PDFTo describe a case of microcephaly, unilateral retinal fold, and familial exudative vitreoretinopathy (FEVR)-like phenotype in the context of 2 variants. A case and its findings were analyzed. A 4-month-old boy with no family history of eye disease presented by referral for management of presumed persistent fetal vasculature in the left eye.
View Article and Find Full Text PDFTo evaluate the visual outcomes with unexplained vision loss during or after silicone oil (SO) tamponade. This multicenter retrospective case series comprised patients with unexplained vision loss associated with SO tamponade or its removal. Eyes with other clear secondary identifiable causes of vision loss were excluded.
View Article and Find Full Text PDFPurpose: To report the clinical characteristics, antibiotic susceptibilities, and review the literature of Burkholderia cepacia complex (BCC) associated endophthalmitis.
Study Design: Retrospective, observational case series.
Methods: Clinical and microbiology records were reviewed for patients evaluated at the Bascom Palmer Eye Institute and diagnosed wisth culture-confirmed endophthalmitis due to BCC.
Article Synopsis
- - The study examines trends in the use of immunosuppressive drugs for non-infectious uveitis among ophthalmologists and how these trends relate to payments from the pharmaceutical industry.
- - Over the years 2014 to 2018, more ophthalmologists reported administering adalimumab (ADA) and repository corticotropin (RCI), while the use of mycophenolate mofetil (MMF) declined.
- - A correlation was found between the increase in ADA and RCI use and industry payments to physicians, although no direct cause-and-effect relationship was established.
Background/purpose: Within the evolving landscape of healthcare in the United States (US), delineating the demographic nuances and financial implications of emergent conditions, such as rhegmatogenous retinal detachment (RRD), is paramount. This study seeks to analyze the demographic and hospital billing amount/cost of service disparities in RRD visits to emergency departments (EDs) nationwide.
Methods: We conducted a retrospective, cross-sectional, population-based study using International Classification of Diseases, 10th revision , and Current Procedural Terminology codes in the 2016 to 2019 Nationwide Emergency Department Sample databases to identify RRD visits.