Publications by authors named "Nicolas Rodondi"
Background: There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aimed to investigate the association between coffee consumption and MACE in AF patients.
View Article and Find Full Text PDFBackground: Atrial fibrillation is an independent risk factor for the development of cognitive impairments. Regular coffee consumption has shown cognitive benefits in healthy individuals. Whether regular consumption reduces cognitive decline in vulnerable patients is controversial.
View Article and Find Full Text PDFContext: Subclinical thyroid dysfunction (ScTD) comprising subclinical hypothyroidism (SHypo) and subclinical hyperthyroidism (SHyper) has been associated with increased risk for cardiovascular events.
Objective: To assess associations between ScTD and cardiovascular risk factors (cvRFs) according to age and sex.
Design And Setting: Pooled individual participant data analysis of large prospective cohort studies from the Thyroid Studies Collaboration.
Article Synopsis
- The study examined the relationship between smoking habits and brain health in patients with atrial fibrillation (AF), focusing on brain lesions and volumes using MRI scans.
- A total of 1,728 patients were analyzed, revealing that heavy smoking and longer smoking duration were linked to reduced gray matter volume and increased risk of white matter lesions (WMLs).
- Additionally, patients who quit smoking for at least 16 years had fewer small noncortical infarcts and smaller WML volumes, indicating that long-term cessation may improve brain health.
Background: Guidelines and studies provide conflicting information on whether type 2 diabetes (T2D) should be considered a coronary heart disease risk (CHD) equivalent in older adults.
Methods: We synthesized participant-level data on 82,723 individuals aged ≥65 years from five prospective studies in two-stage meta-analyses. We estimated multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of T2D (presence versus absence) on a primary composite outcome defined as cardiovascular events or all-cause mortality.
Aims: The benefit of long-term beta-blocker therapy after acute coronary syndromes (ACS) without heart failure in the reperfusion era is uncertain. Two recent randomized trials found conflicting results. The present study assessed the safety of beta-blocker discontinuation within 12 months following ACS with LVEF ≥40%.
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- * This study analyzed data from over 900 high-risk AF patients to compare outcomes between those receiving LAAO and those getting traditional treatment (mostly oral anticoagulants).
- * Results showed no significant differences in stroke or cardiovascular death rates, but LAAO patients experienced significantly less clinically relevant bleeding compared to those on conventional treatments.
Article Synopsis
- Physicians find it challenging to determine if older patients are on statins for primary or secondary prevention due to limited evidence, complicating decisions about continuing or stopping the medication.
- There are concerns about potential negative effects from discontinuing statins, including fear of rebound symptoms and the impact on the patient-physician relationship.
- The study emphasizes the importance of shared decision-making in primary care settings, where PCPs can leverage their long-term relationships with patients to navigate medication management effectively.
Article Synopsis
- The study assessed eligibility for marine omega-3 fatty acid eicosapentaenoic acid (EPA) supplementation in patients with acute coronary syndromes (ACS) in a Swiss cohort, as recommended by 2019 European Society of Cardiology guidelines.
- Out of 2643 patients, 32% were eligible for EPA supplementation one year post-ACS, with higher eligibility rates found in younger individuals, smokers, diabetics, hypertensive patients, and the obese.
- The research indicates that statins and other lipid-lowering therapies could reduce the percentage of these patients eligible for omega-3 supplementation, suggesting a need to address residual cardiovascular risk in those with hypertriglyceridemia.
Background: The influence of atrial fibrillation (AF) and blood pressure (BP) on brain lesions and cognitive function is unclear. We aimed to investigate the association of BP with different types of brain lesions and cognitive decline in patients with AF.
Methods: Overall, 1,213 AF patients underwent standardized brain magnetic resonance imaging at baseline and after 2 years, as well as yearly neurocognitive testing.
An abnormal platelet count (PC) is common in acute venous thromboembolism (VTE) but its relationship with clinical outcomes remains ill-defined. We aimed to explore the association between baseline PC and the long-term risk of clinically relevant outcomes in a prospective cohort of 991 patients with acute VTE. We classified patients into four PC groups: very low (< 100 G/l), low (≥ 100 to < 150 G/l), normal (≥ 150 G/l to ≤ 450 G/l), and high (> 450 G/l).
View Article and Find Full Text PDFBackground: Targeting effective strategies to prevent cognitive decline is key in the aging population. Some diets have been linked to a slower cognitive decline, potentially through reducing inflammation. We aimed at determining the effect of inflammatory dietary patterns (IDPs) on cognitive function in three population-based cohorts.
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- * It included over 2,300 patients, with a focus on comparing outcomes based on how many ECV procedures each patient had undergone.
- * The results indicated no significant link between the number of ECVs and either existing or new brain infarcts, nor with clinical issues like strokes, hospitalizations for heart failure, or mortality.
Purpose: To explore the association between medication use-related factors and health-related quality of life (HRQoL) in older hospitalised multimorbid patients with polypharmacy.
Methods: This cross-sectional study used the intervention arm data of the OPERAM trial (hospitalised patients ≥ 70 years with polypharmacy). HRQoL was assessed using the visual analogue scale (EQ-VAS) and the EQ-5D index score of the EuroQol questionnaire (EQ-5D-5L).
Objectives: Sex differences occur in atrial fibrillation (AF), including age at first manifestation, pathophysiology, treatment allocation, complication rates and quality of life. However, optimal doses of cardiovascular pharmacotherapy used in women with AF with or without heart failure (HF) are unclear. We investigated sex-specific associations of beta-blocker and renin-angiotensin system (RAS) inhibitor doses with cardiovascular outcomes in patients with AF or AF with concomitant HF.
View Article and Find Full Text PDFObjectives: To assess the association between socioeconomic status (SES) and self-reported adherence to preventive measures in Switzerland during the COVID-19 pandemic.
Methods: 4,299 participants from a digital cohort were followed between September 2020 and November 2021. Baseline equivalised disposable income and education were used as SES proxies.
Background: With increasing use of cannabis, we need to know if cannabis use and Body Mass Index (BMI) are associated.
Methods: The Coronary Artery Risk Development in Young Adults Study followed Black and White adults over 30 years with assessments every 2 to 5 years in four centers in the USA. We assessed self-reported current and computed cumulative cannabis exposure at every visit, and studied associations with BMI, adjusted for relevant covariables in mixed longitudinal models.
Objective: To identify and quantify risk factors for in-hospital falls in medical patients.
Data Sources: Six databases (MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, CINAHL, and Google Scholar) were systematically screened until April 11, 2023, to identify relevant articles.
Study Selection: All titles and abstracts of the retrieved articles were independently screened by 2 researchers who also read the full texts of the remaining articles.
Article Synopsis
- After experiencing a pulmonary embolism (PE), many patients struggle with their health-related quality of life (QoL), and this study aimed to see if the severity of PE affects QoL over time.
- Researchers assessed QoL in 546 older patients using specific and generic questionnaires at baseline, 3 months, and 12 months, discovering that those with severe PE had significantly worse QoL scores compared to those with nonsevere PE.
- The findings suggest that severe PE is associated with ongoing impairments in both PE-specific and physical QoL throughout the year following the event.
Article Synopsis
- * In a study of 1,265 AF patients, those with heart failure (HFpEF and HFrEF) faced significantly higher risks of hospitalisation due to heart failure, mortality, and progression of AF compared to those without HF.
- * HFpEF patients received the fewest rhythm control interventions and reported the poorest quality of life, indicating a critical need for better treatments in this population.
Background: Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and without familial hypercholesterolemia (FH) 5 years after ACS.
Methods: We studied patients hospitalized for ACS between 2009 and 2017 in a Swiss multicenter prospective cohort study.
Article Synopsis
- Stroke is a major risk for patients with atrial fibrillation (AF), potentially linked to issues with the autonomic nervous system.
- A study involving 1,922 AF patients analyzed various heart rate variability (HRV) measures to see if they correlate with stroke risk.
- Results showed that a specific HRV measure (HRVI <15) in patients with normal sinus rhythm (SR) significantly predicted stroke risk, while no HRV measures were linked to stroke risk in the AF group.
Background: Benzodiazepines and other sedative hypnotic drugs (BSHs) are frequently prescribed for sleep problems, but cause substantial adverse effects, particularly in older adults. Improving knowledge on barriers, facilitators and needs of primary care providers (PCPs) to BSH deprescribing could help reduce BSH use and thus negative effects.
Methods: We conducted a mixed methods study (February-May 2023) including a survey, semi-structured interviews and focus groups with PCPs in Switzerland.