Nuclear position controls the activity of cortical actomyosin networks powering simultaneous morphogenetic events.

Tissue morphogenesis shapes epithelial sheets via cell remodelling to form functional living organisms. While the mechanisms underlying single morphogenetic events are well studied, how one tissue undergoes multiple concomitant shape changes remains largely unexplored. To tackle this, we study the process of simultaneous mesoderm folding and extension in the gastrulating Drosophila embryo.

Introduction. Making work better.

From the premise that better work makes for better societies, the challenge, taken up in the introduction to this special issue of , is to explore what makes work better, or worse, and how it can be improved. As a wide variety of experiments shape our economies and communities for the future, a key challenge is to engage in shared learning about these processes in order to stimulate a dialogue between the aspiration for better work and the conditions likely to hinder or facilitate making work better. It is an invitation to move from narrow conceptions of job quality to a broader lens of how world-of-work actors strategise, innovate and incorporate uncertainty into their search for sustainable solutions for better work.

An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing.

Pathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection.