Publications by authors named "Nicolas Noriega"

Background: Matrix metalloproteinase 7 (MMP-7) is a novel biomarker for diagnosis of biliary atresia (BA), the most common cholestatic liver disease in infancy. There is a pressing need to determine the utility of MMP-7 levels in infants with congenital heart disease (CHD) to avoid unnecessary invasive diagnostic procedures in this high-risk population. We investigated the utility of MMP-7 in discriminating BA from non-BA cholestasis in infants with CHD and whether MMP-7 elevation was present in infants requiring treatment for clinically significant PH.

View Article and Find Full Text PDF

Background: Matrix metalloproteinase 7 (MMP-7) is a novel biomarker for diagnosis of biliary atresia (BA), the most common cholestatic liver disease in infancy. There is a pressing need to determine the utility of MMP-7 levels in infants with congenital heart disease (CHD) to avoid unnecessary invasive diagnostic procedures in this high-risk population. We investigated the utility of MMP-7 in discriminating BA from non-BA cholestasis in infants with CHD and whether MMP-7 elevation was present in infants requiring treatment for clinically significant PH.

View Article and Find Full Text PDF
Article Synopsis
  • The study explores how Prominin-1 (Prom1), a component of epithelial cells, influences the healing of the extrahepatic bile duct epithelium after injury, particularly in cholangiopathies.
  • Researchers found that Prom1-expressing progenitor cells in the extrahepatic bile duct quickly proliferate and differentiate into cholangiocytes to restore the epithelium following injury.
  • Prom1 deficiency resulted in significant abnormalities in peribiliary glands and impaired organoid function, highlighting its crucial role in maintaining cell structure and promoting recovery after bile duct damage.
View Article and Find Full Text PDF
Article Synopsis
  • Researchers hypothesized that the TWEAK/FN14 signaling pathway stimulates the proliferation of these Prom1-expressing HPCs, enhancing liver fibrosis in BA.
  • Experimental results showed that blocking FN14 reduced liver damage and ductular reactions in a mouse model, while signs of activation in BA patients suggested that TWEAK/FN14 is linked to poor outcomes after surgery for bile drainage.
View Article and Find Full Text PDF

Objective: To present outcomes of a simplified GreenLight laser enucleation of the prostate (GreenLEP) technique and to inform urologists considering incorporation of enucleation into their practice.

Methods: We reviewed all consecutive GreenLEPs by a single surgeon from 2015 to 2018. Baseline patient characteristics, pre-enucleation prostate volume, enucleated adenoma weight, blood loss, lasering time, and energy utilized were recorded.

View Article and Find Full Text PDF

Objective: To present a simplified technique for GreenLight laser enucleation of the prostate (GreenLEP), designed to reduce the learning curve commonly associated with endoscopic prostate enucleation.

Materials And Methods: GreenLEP is a novel endoscopic treatment for BPH which allows for durable resection of large glands with minimal energy use, minimal bleeding and has been shown to be non-inferior to holmium laser enucleation of the prostate (HoLEP). Furthermore, GreenLEP has been shown to be superior to GreenLight PVP For glands >80 g with respect to operative time, unplanned hospital readmission and decrease in post treatment PSA and prostate size.

View Article and Find Full Text PDF

Anxiety and depression are two important clinical entities associated not only with mental health, but to health and illness in general. However, professionals in most of the non-psychiatric health settings avoid referring to either one. The prime objective of this work is to review publications showing the important correlation between anxiety and depression and various diseases.

View Article and Find Full Text PDF

This study aims at determining whether there was an association among anxiety, depression and allergic illnesses. It suggests the proper therapeutic treatment. During a year, our research work team worked with a group of 82 female and male patients (from 13 to 76 years old) who suffered from various types of allergies.

View Article and Find Full Text PDF