Publications by authors named "Nicolas M Perney"
Article Synopsis
- Coherent anti-Stokes Raman scattering (CARS) microscopy is utilized for the first time to assess the protein structure of polyglutamine aggregates in living organisms, translating in vitro findings into an in vivo analysis.
- The study shows that synthesized polyglutamine peptides form a rigid, cross β-sheet structure, as confirmed by Raman spectroscopy and X-ray diffraction methods.
- The integration of CARS and fluorescence microscopy in C. elegans reveals distinct patterns of polyglutamine, highlighting areas with enhanced CARS signals compared to surrounding tissues, indicating its structural characteristics.
Here we present the first evidence showing that eukaryotic cells can be stably trapped in a single focused Gaussian beam with an orientation that is defined by the nucleus. A mammalian eukaryotic cell (in suspension) is trapped and is re-oriented in the focus of a linearly polarized Gaussian beam with a waist of dimension smaller than the radius of the nucleus. The cell reaches a position relative to the focus that is dictated by the nucleus and nuclear components.
View Article and Find Full Text PDFComprehensive reflectivity mapping of the angular dispersion of nanostructured arrays comprising of inverted pyramidal pits is demonstrated. By comparing equivalently structured dielectric and metallic arrays, diffraction and plasmonic features are readily distinguished. While the diffraction features match expected theory, localised plasmons are also observed with severely flattened energy dispersions.
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