Publications by authors named "Nicolas Kramser"
Article Synopsis
- The study evaluated three-year outcomes of endovascular treatment (EVT) for peripheral arterial disease (PAD) in patients with severe calcified lesions in the common femoral artery (CFA), using data from the Duesseldorf PTA Registry.
- A total of 150 patients were analyzed, with 66 undergoing rotational excisional atherectomy (REA) followed by drug-coated balloon (DCB) angioplasty, and 84 receiving DCB alone; the procedural success rate was high at 97%.
- Findings indicated that EVT is safe and effective, showing high primary and secondary patency rates, low major adverse limb events (MALEs), and major adverse cardiovascular events (MACEs) after three years, suggesting that RE
The search for the best therapeutic approach in cardiopulmonary resuscitations (CPR) remains open to question. In this study, we evaluated if Amiodarone administration during CPR was associated with short-term mortality or neurological development. A total of 232 patients with sudden cardiac arrest (CA) with shockable rhythms were included in our analysis.
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- The study investigates how aortic valve stenosis (AS) impacts endothelial function independently of usual cardiovascular risk factors in both mice and human cohorts.
- The researchers found that AS led to systemic endothelial dysfunction characterized by increased extracellular hemoglobin (eHb), nitric oxide consumption, and mechanical stress in the aorta.
- Treatment methods, including the use of haptoglobin and transcatheter aortic valve replacement, were effective in restoring endothelial function in both experimental and clinical settings.
: Loss of functional capacity is one of the hallmarks in cardiovascular aging. Cocoa flavanols (CF) exert favorable effects on endothelial function, blood pressure, and inflammation. These cardiovascular health markers worsen with increasing age and limit functional exercise capacity.
View Article and Find Full Text PDF: The transradial approach for coronary angiography is associated with fewer complications and preferred over the femoral approach. Injury to the radial artery (RA) endothelium elicits intimal hyperplasia, possibly resulting in total occlusion and limb functional decline. Flavanols are known to improve endothelial function.
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- A study examined the relationship between serum phosphate levels and patient outcomes in cardiac arrest (CA) victims who achieved return of spontaneous circulation (ROSC).
- Elevated phosphate levels (greater than 2.7 mmol/L) were found to significantly predict higher mortality rates and impaired neurological function in CA patients upon discharge.
- The research included analysis of data from both a German hospital and a larger multi-centric cohort, finding consistent results that suggest phosphate level testing may enhance prognostic accuracy after CPR.
Thromboembolic events (TEs) are a feared complication in patients supported by a continuous-flow left ventricular assist device (LVAD). The aim of the study was to analyze the role of circulating microparticles (MPs) in activating the coagulation system in LVAD patients, which might contribute to the occurrence of TEs. First, we analyzed the effect of LVAD support on endothelial function, on the levels of endothelial MPs (EMPs) and platelet MPs (PMPs), and on the procoagulative activity of circulating MPs (measured as MP-induced thrombin formation) before LVAD implantation, post-implantation, and at a 3 month follow-up (n = 15).
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