Publications by authors named "Nicolas Gelvez"
Article Synopsis
- - Cytidine to Uridine (C-to-U) RNA editing, facilitated by APOBEC1 (A1), plays a crucial role in biological processes, particularly in regulating cholesterol metabolism through editing ApoB mRNA.
- - A1 relies on cofactors like A1CF and RBM47 to form an "editosome" for effective RNA editing, while Syncrip acts as a potential regulator of A1 without directly participating in the editing.
- - The study introduced a new cofactor, RBM46, which enhances A1's editing capabilities on ApoB mRNA and identified novel cellular RNA targets for the A1/RBM46 editosome using advanced sequencing techniques.
Cytidine (C) to Uridine (U) RNA editing is a post-transcription modification that is involved in diverse biological processes. APOBEC1 (A1) catalyzes the conversion of C-to-U in RNA, which is important in regulating cholesterol metabolism through its editing activity on ApoB mRNA. However, A1 requires a cofactor to form an "editosome" for RNA editing activity.
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