Publications by authors named "Nicolas Fink"
Idiopathic inflammatory myopathy (IIM) represents a rare group of autoimmune conditions resulting in muscle weakness and includes polymyositis, dermatomyositis, immune-mediated necrotizing myopathy (IMNM), overlap myositis, and inclusion body myositis. Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibody IMNM represents a rare but increasingly recognized subtype of IIM. Here we report a case of a 65-year-old woman on rosuvastatin who presented with two months of progressive proximal muscle weakness, significant truncal weakness, and elevated creatine kinase concerning for rhabdomyolysis and inflammatory myopathy.
View Article and Find Full Text PDFBackground: Low rates of heart failure (HF) hospitalizations were observed during the 2020 peak of the COVID-19 pandemic. Additionally, posthospitalization follow-up transitioned to a predominantly telemedicine model. It is unknown whether the shift to telemedicine impacted disparities in posthospitalization follow-up or HF readmissions.
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- VHL disease is a genetic condition linked to mutations in the VHL gene, leading to various tumors, most notably hemangioblastomas in the brain and spine, and clear cell renal cell carcinoma.
- The new treatment belzutifan, a HIF-2α inhibitor, shows effectiveness with a 30% response rate and significant tumor size reduction in hemangioblastomas, marking a potential breakthrough since no effective systemic therapies were available previously.
- While belzutifan is generally well tolerated, it is associated with common side effects like anemia, hypoxia, and fatigue, and there's still a lack of long-term data on its safety and impact on fertility.
Evaluating same-source bias in the association between neighbourhood characteristics and depression in a community sample from Toronto, Canada.
Soc Psychiatry Psychiatr Epidemiol
October 2019
Background And Purpose: It is common in prior studies of the influence of neighbourhood characteristics on mental health to use participant-assessed neighbourhood exposures, which can lead to same-source bias since an individual's mental health status may influence their judgement of their neighbourhood. To avoid this potential bias, we evaluated the use of individually assessed neighbourhood exposures to understand how they compare to collectively assessed measures (by aggregating multiple responses within the same neighbourhood). This would increase the validity of the measure by decoupling the neighbourhood measure from an individual's mental health status.
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