Publications by authors named "Nicolas Eychenne"
Basic Res Cardiol
June 2024
Article Synopsis
- - Hypercholesterolemia is a significant risk factor for heart diseases, and cholesterol can negatively affect heart function even without it, particularly through the harmful buildup of cholesterol in heart mitochondria during ischemic events.
- - In experiments with rats, the study found that inhibiting cholesterol synthesis with pravastatin reduced harmful cholesterol buildup in mitochondria and protected them during ischemia-reperfusion.
- - The research highlighted a new interaction between translocator protein (TSPO) and steroidogenic acute regulatory protein (STAR) that regulates cholesterol accumulation in mitochondria, suggesting potential therapeutic targets to address mitochondrial dysfunction in heart conditions.
