Publications by authors named "Nicolas Ehnert"
Article Synopsis
- The study investigates the role of C5aR2, a receptor related to inflammation, in hypertension and its effects on kidney injury, revealing that C5aR2 deficiency does not impact hypertensive damage caused by angiotensin II in mice.
- C5aR2 expression is primarily found in immune cells like dendritic cells and monocytes, both in mice and hypertensive human patients, suggesting a potential link between immune response and hypertension.
- Despite the high expression of C5aR2 in these immune cells, results indicate that its absence does not lead to differences in blood pressure or renal and cardiac injuries in models of hypertension induced by angiotensin II.
Background: Complement may drive the pathology of hypertension through effects on innate and adaptive immune responses. Recently an injurious role for the anaphylatoxin receptors C3aR (complement component 3a receptor) and C5aR1 (complement component 5a receptor) in the development of hypertension was shown through downregulation of Foxp3 (forkhead box protein 3) regulatory T cells. Here, we deepen our understanding of the therapeutic potential of targeting both receptors in hypertension.
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