Publications by authors named "Nicolas David Maldonado-Rodriguez"
Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations.
Juan Fernando Parada-Márquez Nicolás David Maldonado-Rodriguez Paula Triana-Fonseca Nora Constanza Contreras-Bravo Carlos Alberto Calderón-Ospina
Front Pharmacol
March 2023
Article Synopsis
- The study investigates genetic variability related to adverse drug reactions (ADRs) in anesthetic drugs among a Colombian sample of 625 healthy individuals.
- It analyzes 14 genes involved in the metabolism of these drugs using whole-exome sequencing, identifying 148 molecular variants that influence therapeutic responses, primarily rare and novel missense variants.
- Comparisons reveal that the Colombian population has a distinct pharmacogenomic profile for anesthetic drugs, with significant differences in allele frequencies compared to other populations.