Publications by authors named "Nicolas Dagany"
Microorganisms
November 2023
Article Synopsis
- * Spike proteins lower the expression of key genes involved in lipid metabolism and LD formation in PBMCs, suggesting a disruption in normal lipid handling.
- * Despite LD formation in PBMCs, the presence of spike proteins did not trigger an inflammatory response, indicating that this lipid accumulation may not be linked to cell activation during COVID-19 infection.
Article Synopsis
- Patrolling Ly6C(-) monocytes are important immune cells involved in inflammation and pathogen defense, and they express high levels of the receptor S1PR5, similar to NK cells.
- The study found that mice lacking S1PR5 (S1pr5(-/-) mice) have no Ly6C(-) monocytes in their bloodstream but have normal amounts in the bone marrow, indicating S1PR5 is crucial for their exit from the bone marrow.
- Interestingly, the research showed that S1P (the ligand for S1PR5) does not attract these monocytes or affect their survival in lab conditions, suggesting S1PR5 plays a role in monocyte movement that is not dependent on S1P signaling
