Publications by authors named "Nicolas D Dho"
New adjuvant strategies are needed to improve protein-based subunit vaccine immunogenicity. We examined the potential to use nanostructure of 6-O-ascorbyl palmitate to formulate ovalbumin (OVA) protein and an oligodeoxynucleotide (CpG-ODN) (OCC). In mice immunized with a single dose, OCC elicited an OVA-specific immune response superior to OVA/CpG-ODN solution (OC).
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- This study investigates the effects of cytokine storms in COVID-19 patients from Córdoba, Argentina, comparing data from the first two waves of the pandemic to understand links between demographics, comorbidities, and disease outcomes.
- Results showed that patients during the second wave were younger and had fewer comorbidities, with distinct cytokine and chemokine profiles, while pre-existing conditions did not significantly impact cytokine levels.
- The research identified specific inflammatory markers, such as IL-6 and C-reactive protein, that could help predict patient outcomes, particularly differentiating between mortality and recovery during the first wave of infections.
Although the baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects lepidopteran invertebrates as natural hosts, represents an efficient vector for vaccine development. Baculovirus surface display induces strong humoral responses against viruses and parasites. A novel strategy based on capsid display carrying foreign antigens in the AcMNPV particle further improved the immune response by eliciting CD8 T cell activation.
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