We studied short- and long-term effects of intravitreal injection of -methyl-d-aspartate (NMDA) on melanopsin-containing (m) and non-melanopsin-containing (Brn3a) retinal ganglion cells (RGCs). In adult SD-rats, the left eye received a single intravitreal injection of 5µL of 100nM NMDA. At 3 and 15 months, retinal thickness was measured in vivo using Spectral Domain-Optical Coherence Tomography (SD-OCT).
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