Publications by authors named "Nicolas Cohn-Inostroza"
The preparation of sophisticated hierarchically structured and cytocompatible hydrogel scaffolds is presented. For this purpose, a photosensitive resin was developed, printability was evaluated, and the optimal conditions for 3D printing were investigated. The design and fabrication by additive manufacturing of tailor-made porous scaffolds were combined with the formation of surface wrinkled micropatterns.
View Article and Find Full Text PDFPatients with bone diseases often experience increased bone fragility. When bone injuries exceed the body's natural healing capacity, they become significant obstacles. The global rise in the aging population and the escalating obesity pandemic are anticipated to lead to a notable increase in acute bone injuries in the coming years.
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- The study examines how the surface topography and composition of dental implants affect mesenchymal cell functions essential for osseointegration, specifically focusing on cell adhesion, proliferation, and differentiation.
- Various commercial titanium implants with different surface treatments were characterized, comparing sandblasted/acid-etched and calcium phosphate treatments, while a smooth surface served as a control.
- Results indicated that the Biounite implant, featuring a regular topography and calcium phosphate treatment, had superior protein adsorption and mesenchymal stem cell adhesion compared to other implants tested.
Fabrication and Testing of Multi-Hierarchical Porous Scaffolds Designed for Bone Regeneration via Additive Manufacturing Processes.
Polymers (Basel)
September 2022
Article Synopsis
- Bone implants and replacements face challenges due to limited donor availability and high rejection rates, prompting the use of tissue engineering strategies to create new solutions.
- This research focused on developing a cellular scaffold with a complex internal structure using 3D printing and salt leaching, along with a biocompatible hydrogel film that formed wrinkled micropatterns to enhance contact area and biocompatibility.
- The study found that while adding nano-hydroxyapatite particles slightly affected the material's mechanical strength, it didn't significantly boost cell viability; however, the combination of the hydrogel and porous structure improved cell viability compared to untreated samples.
Micrometer-sized double emulsions and antibubbles were produced and stabilized via the Pickering mechanism by colloidal interfacial layers of polymeric nanoparticles (NPs). Two types of nanoparticles, consisting either of polylactic acid (PLA) or polylactic--glycolic acid (PLGA), were synthesized by the antisolvent technique without requiring any surfactant. PLA nanoparticles were able to stabilize water-in-oil (W/O) emulsions only after tuning the hydrophobicity by means of a thermal treatment.
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