Publications by authors named "Nicolas Bonetto"
Proc Natl Acad Sci U S A
June 2024
Article Synopsis
- Intracellular bacterial pathogens manipulate host cell processes to create a suitable environment for their survival, with the Q fever bacterium using its Type 4 secretion system to form a specialized vacuole known as a CCV.
- The study identifies that the bacterial effector protein Vice interacts with specific lipids (like phosphatidylserine) and triggers the formation of compartments similar to CCVs in host cells, demonstrating its role in both vacuole formation and stabilization.
- Vice performs dual functions: first aiding in the internalization of vacuoles through macropinocytosis, and then disrupting the ESCRT machinery to maintain these compartments, highlighting its key role in bacterial replication and survival.
