Publications by authors named "Nicolas Berrodier"
Nat Commun
September 2024
Article Synopsis
- Researchers discovered a specific motif (YDDΦxΦ) in NF-κB pathway substrates that helps these substrates dock with IKK dimers, showing a link between how well they bind and IKK activity, particularly in IκBα phosphorylation and degradation.
- The study suggests that a certain phosphorylation event on this motif reduces its ability to dock with IKK, which can influence NF-κB signaling, and also indicates that disrupting IKK dimerization disrupts substrate binding.
