Publications by authors named "Nicolas Berbenetz"
Article Synopsis
- There is a lack of Canadian studies analyzing the costs of catheter ablation (CA) for atrial fibrillation (AF) using patient-specific data; this study aims to fill that gap.
- A cost analysis was conducted on AF patients in Nova Scotia, comparing health care costs 2 years before and after CA, highlighting a significant decrease in hospitalizations and ER visits post-ablation.
- Although the immediate costs of the treatment were high, the overall reduction in health care usage suggests that CA could be a cost-effective solution for AF treatment in the long run.
Preoperative and Intraoperative Imaging during Transvenous Lead Extraction.
Card Electrophysiol Clin
December 2024
Transvenous lead extraction is performed for device infection, lead failure, or to provide access for additional leads/device upgrade. A patient-centered risk assessment for transvenous lead extraction can be determined using a combination of clinical factors and several imaging modalities. Predicting a complex lead extraction, for example, one that will require powered tools or the use of a femoral approach, is aided by pre-procedural imaging and clinical assessment.
View Article and Find Full Text PDFBackground: Cardiac implantable electronic device (CIED) infection is a costly and highly morbid complication. Perioperative interventions, including the use of antibiotic pouches and intensified perioperative antibiotic regimens, have demonstrated marginal efficacy at reducing CIED infection. Additional research is needed to identify additional interventions to reduce infection risk.
View Article and Find Full Text PDFBackground And Objectives: The serratus plane block (SPB) is a novel chest wall interfascial plane block. Its analgesic efficacy compared with non-block care and paravertebral block (PVB) is unestablished.
Methods: We conducted a random-effects meta-analysis of randomized controlled trials (RCTs) recruiting adult surgical patients that compared a SPB to non-block care or PVB for postoperative analgesia.
Background: Non-invasive positive pressure ventilation (NPPV) has been used to treat respiratory distress due to acute cardiogenic pulmonary oedema (ACPE). We performed a systematic review and meta-analysis update on NPPV for adults presenting with ACPE.
Objectives: To evaluate the safety and effectiveness of NPPV compared to standard medical care (SMC) for adults with ACPE.
Costs of end of life care for patients who have advanced heart failure (HF) are increasing. There is a perception that many of these patients receive aggressive treatments near the end of life. However, actual patterns of care are unclear.
View Article and Find Full Text PDFBackground: Caudal block is commonly used to provide postoperative analgesia after pediatric surgery in the lower abdomen. Typically administered as a single-shot technique, 1 limitation of this block is the short duration of analgesia. To overcome this, dexamethasone has been used as an adjuvant to prolong block duration.
View Article and Find Full Text PDFBackground: Much uncertainty exists as to whether peri-operative goal-directed therapy is of benefit.
Objectives: To discover if peri-operative goal-directed therapy decreases mortality and morbidity in adult surgical patients.
Design: An updated systematic review and random effects meta-analysis of randomised controlled trials.
Background And Objectives: Dexamethasone is a useful adjuvant in regional anesthesia that is used to prolong the duration of analgesia for peripheral nerve blocks. Recent randomized controlled trials (RCTs) have demonstrated conflicting results as to whether perineural versus intravenous (IV) administration is superior in this regard, and the perineural use of dexamethasone remains off-label. Therefore, we sought to perform a systematic review and meta-analysis of RCTs.
View Article and Find Full Text PDFMineralocorticoid receptor antagonists for heart failure: systematic review and meta-analysis.
BMC Cardiovasc Disord
December 2016
Background: Mineralocorticoid receptor antagonists (MRAs) have been associated with improved patient outcomes in patients with heart failure with reduced ejection fraction (HFrEF) but not preserved ejection fraction (HFpEF). We conducted a systematic review and meta-analysis of selective and nonselective MRAs in HFrEF and HFpEF.
Methods: We searched Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE.
Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure. The availability of genome-wide maps of nucleosome positions has led to an explosion of information about how nucleosomes are assembled at transcription start sites, but no similar maps exist for DNA replication origins.
View Article and Find Full Text PDFModulating gene dose is an effective way to alter protein levels and modify phenotypes to understand gene function. In addition, combining gene-dose alleles with chemical perturbation can provide insight into drug-gene interactions. Here, we present a strategy that combines diverse loss-of-function alleles to systematically modulate gene dose in Saccharomyces cerevisiae.
View Article and Find Full Text PDFArticle Synopsis
- Lsr2 is a small protein found in Mycobacterium that plays a key role in regulatory processes related to cell wall biosynthesis and antibiotic resistance, although its molecular mechanisms are still not fully understood.
- Recent biochemical studies indicate that Lsr2 can bridge distant segments of DNA, suggesting it contributes to the organization of the nucleoid within the cell.
- Mutational analysis demonstrated that both the ability of Lsr2 to bind DNA and to form protein aggregates are crucial for its normal function, establishing it as a novel DNA bridging protein in bacteria outside the Enterobacteriaceae family.