Efficacy of methadone for the management of postoperative pain in laparoscopic cholecystectomy: A randomized clinical trial.

Background: Postoperative pain management contributes to reducing postoperative morbidity and unscheduled readmission. Compared to other opioids that manage postoperative pain like morphine, few randomized trials have tested the efficacy of intraoperatively administered methadone to provide evidence for its regular use or be included in clinical guidelines.

Methods: We conducted a randomized clinical trial comparing the use of intraoperative methadone to assess its impact on postoperative pain.