Synopsis of recent research by authors named "Nicolas Anselmino"
- Nicolas Anselmino's recent research focuses on advancing our understanding of molecular characteristics and treatment responses in prostate cancer, particularly in relation to aggressive forms like neuroendocrine prostate cancer (NEPC) and its metabolic adaptations during progression.
- A key finding includes the development of a machine learning-driven 7-gene stemness signature that effectively predicts progression in NEPC, as well as integrating extensive molecular analyses of patient-derived xenografts to enhance the representation of prostate cancer models.
- Additionally, his work highlights the challenges in using patient-derived models, underscores the significance of pathways like the interferon-gamma response in COVID-19, and explores metabolic rewiring in metastatic prostate cancer, emphasizing the need for novel therapeutic strategies.
