Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.

Background: Motor neuron disease represents a group of progressive and incurable diseases that are characterised by selective loss of motor neurons, resulting in an urgent need for rapid identification of effective disease-modifying therapies. The MND SMART trial aims to test the safety and efficacy of promising interventions efficiently and definitively against a single contemporaneous placebo control group. We now report results of the stage two interim analysis for memantine and trazodone.

Lost in translation.

The story of the ‘United to End MND’ £50m government research funding campaign by the patients who started the endeavour.

IWII Wound Infection in Clinical Practice consensus document: 2022 update.

Wound infection is a major challenge for clinicians globally, with accurate and timely identification of wound infection being critical to achieving clinical and cost-effective management, and promotion of healing. This paper presents an overview of the development of the International Wound Infection Institute (IWII)'s 2022 Wound Infection in Clinical Practice consensus document. The updated document summarises current evidence and provides multidisciplinary healthcare providers with effective guidance and support on terminology, paradigms related to biofilm, identification of wound infection, wound cleansing, debridement and antimicrobial stewardship.

Novel Smart Sensor Platform for Monitoring Multiple Pressure Injury Risk Factors: A Feasibility Study in a Post-Acute Care Facility.

Introduction: Posture, temperature, and moisture have been identified as critical modifiable risk factors in pressure injury (PI) development. Microclimate is defined as temperature and humidity at the interface of the support surface and body. To our knowledge, no studies have used sensor technology to measure these parameters simultaneously in real time.

One child, one appointment: how institutional discourses organize the work of parents and nurses in the provision of childhood vaccination for First Nations children.

To effectively support childhood vaccine programs for First Nations Peoples, Canada's largest population of Indigenous Peoples, it is essential to understand the context, processes, and structures organizing vaccine access and uptake. Rather than assuming that solutions lie in compliance with current regulations, our aim was to identify opportunities for innovation by exploring the work that nurses and parents must do to have children vaccinated. In partnership with a large First Nations community, we used an institutional ethnography approach that included observing vaccination clinic appointments, interviewing individuals involved in childhood vaccinations, and reviewing documented vaccination processes and regulations (texts).

Bid from the Association for the Advancement of Wound Care.

The Association for the Advancement of Wound Care sets out its bid for the WUWHS 2026 Congress to be held in Chicago, Illinois, US.

An international consensus on device-related pressure ulcers: SECURE prevention.

and colleagues present the findings of their review, ccna2@juno.com.

The hierarchy of evidence in advanced wound care: The social organization of limitations in knowledge.

In this article, we discuss how we used institutional ethnography (Institutional ethnography as practice, Rowman & Littlefield, Lanham, MD and 2006) to map out powerful ruling relations that organize nurses' wound care work. In recent years, the growing number of people living with wounds that heal slowly or not at all has presented substantial challenges for those managing the demands on Canada's publicly insured health-care system. In efforts to address this burden, Canadian health-care administrators and policy-makers rely on scientific evidence about how wounds heal and what treatments are most effective.

Predicting pressure ulcer risk.

The Braden scale is a widely used pressure risk assessment tool and it is, therefore, essential to ensure that the tool is reliable and valid. Several studies have questioned the predictive validity of the Braden scale (Nixon and McGough, 2001). Bergstrom et al (1998) used a quantitative research paradigm to evaluate the effectiveness of the Braden scale in predicting which patients who are at risk of developing pressure ulcers in three different clinical settings in the USA.