Publications by authors named "Nicola U. Zitzmann"

The technical development of implant-supported fixed dental prostheses (iFDP) initially concentrated on the computer-aided manufacturing of prosthetic restorations (CAM). Advances in information technologies have shifted the focus for optimizing digital workflows to AI-based processes for design (CAD). This pre-clinical pilot trial investigated the feasibility of the automatic design of three-unit iFDPs using CAD software (Dental Manger 2021, 3Shape; DentalCAD 3.

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Article Synopsis
  • The article discusses a clinical case involving a 44-year-old woman suffering from erosive tooth wear due to bulimia and bruxism, focusing on restoring her vertical dimension of occlusion (VDO) using minimally invasive methods.
  • After a period of therapy with a Michigan splint, the patient required full mouth prosthetic rehabilitation, leading to the decision to slightly increase her VDO by 1 mm.
  • The treatment included creating thin lithium disilicate ceramic restorations for her teeth, demonstrating that effective and aesthetic restoration can be achieved with minimal invasiveness.
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Objectives: To investigate if the fracture load of implant-supported cantilever fixed dental prostheses (ICFDPs) in the anterior region is affected by the implant type and the aging protocol.

Materials And Methods: Sixty ICFDPs were prepared using multilayer monolithic zirconia for restoring bone-level (BL) and tissue-level (TL) titanium-zirconium implants. Fracture load was measured at baseline (no aging) or after aging in a chewing simulator loading the implant crown or the cantilever in a 30° angle (n = 10 per group).

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As patients in a dental or medical context, persons find themselves in a vulnerable, exceptional psychological and physical situation, in which the solution-oriented regulation of emotions requires mindful, systemic communication. This review describes typical placebo and nocebo effects in verbal, paraverbal and non-verbal communication and their impact on patients and their relationship with dental or medical professionals. In addition, a training curriculum for second-year undergraduate dental master’s students is described, that not only provides students with the necessary competences for solution-oriented systemic communication, but also enables them to experience its effectiveness in the clinical context.

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While peri-implant mucositis relies solely on clinical parameters, radiological assessment becomes indispensable for diagnosing peri-implantitis. Intraoral radiography, with its simplicity of application, low radiation exposure, and adequate representation of peri-implant structures, stands out as the standard of care for both immediate and follow-up assessments. Standardization by custom-made radiologic splints allows for excellent comparability with previous images and allows for the determination of even small changes in contour and density of the peri-implant bone.

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Oral healthcare among the frail is an underestimated geriatric care element. While neglected oral health (OH) is a well-established risk factor for frailty, frailty can be a risk factor for subsequent OH problems. The cross-sectional investigation nested into the SAPALDIA sub-cohort of citizens aged 52 years and older, aims to stimulate longitudinal research into aspects that accelerate poor OH among frail individuals.

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Article Synopsis
  • - The study aimed to evaluate the medium-term survival of Dalbo-Rotex retention elements in dental prosthetics, exploring risks for complications and economic aspects.
  • - Out of 76 Dalbo-Rotex elements assessed in 45 patients, the survival rate was 84.2%, but complications occurred in over 42% of cases, leading to 5-year survival and success rates of 62.4% and 35.6%, respectively.
  • - Patients reported high satisfaction with prosthesis retention, and regular dental visits significantly improved oral health compared to less frequent check-ups, making Dalbo-Rotex a cost-effective retention option.
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Objectives: To simulate the replacement of a premolar with an implant-supported cantilever fixed dental prosthesis (ICFDP) and how the fracture load is affected by implant type, positioning within the zirconia blank, and aging protocol.

Materials And Methods: Seventy-two ICFDPs were designed either within the enamel- or dentin layer of a 4Y-PSZ blank for bone-level and tissue-level titanium-zirconium implants. Fracture load was obtained on the cantilever at baseline (no aging) or after aging in a chewing simulator with the load applied within the implant axis (axial aging) or on the cantilever (12 groups with n = 6).

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Objective: The composition of universal adhesives is highly diverse. The purpose of this in vitro study was to compare the shear bond strength of a composite with five different universal adhesives to human enamel and dentin.

Materials And Methods: The shear bond strength of a composite (G-aenial Universal Injectable) to human enamel and dentin was tested in selective enamel etching mode before and after thermocyclic aging (10,000 cycles) using five different universal adhesive systems (Adhese Universal VivaPen, Clearfil Universal Bond Quick, G-Premio Bond, Prime&Bond active, and Scotchbond Universal Plus).

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Introduction: This study analysed whether the SAZAMED (Self-assessment for dentistry studies) manual test conducted as an exercise or examination in the first year of dental studies, and the official aptitude test for medical studies (EMS), can predict future performance of dental students.

Materials And Methods: Students enrolled in the dental curriculum at the University of Basel between 2009/10 and 2019/20 were categorized: Group A conducted the SAZAMED in the third bachelor year (BA) and second master year (MA), group B practiced in the first and third BA and second MA and group C had to pass the test in the first BA with repetition in the third BA and second MA. SAZAMED comprised (i) wire bending, (ii) modelling sphere and cube, (iii) drawing mirror-inverted and (iv) indirect drawing over a mirror.

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Purpose: The aim of this review was to evaluate the survival rates of restorations utilizing titanium base abutments (TBA) for restoring single-unit implant prostheses.

Materials And Methods: This review was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. The focus question was: In patients who require the restoration of a single dental implant utilizing a titanium base abutment, what are the determining factors and outcomes relating to implant prosthesis prognosis and survival? A comprehensive search of databases (PubMed, EMBASE, and Cochrane Library) was conducted on 16 April 2023 and updated on 5 May 2023.

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Objectives: Composition of implant material and its surface structure is decisive for oral biofilm accumulation. This study investigated biofilm formation on eight different materials.

Materials And Methods: Eighteen healthy subjects wore intraoral splints fitted with two sets of eight materials for 24 h: zirconia [ZrO ]; silver-gold-palladium [AgAuPd]; titanium zirconium [TiZr]; Pagalinor [PA]; hydroxyapatite [HA]; silver-platinum [AgPt]; titanium aluminum niobium [TAN]; titanium grade4 [TiGr4].

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Objective: This article provides an overview of the implications of ChatGPT and other large language models (LLMs) for dental medicine.

Overview: ChatGPT, a LLM trained on massive amounts of textual data, is adept at fulfilling various language-related tasks. Despite its impressive capabilities, ChatGPT has serious limitations, such as occasionally giving incorrect answers, producing nonsensical content, and presenting misinformation as fact.

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Article Synopsis
  • Digital applications have revolutionized prosthodontic therapy, leading to a systematic review that updated the findings on complete digital workflows for fixed dental prostheses, focusing on recent literature from 2016 to 2022.
  • A total of 16 studies involving 440 patients and 658 restorations were analyzed, with the majority centered on implant therapy, highlighting outcomes like time efficiency, precision, and patient satisfaction.
  • The evidence supports the effectiveness of complete digital workflows for implant-supported crowns, showing they perform comparably to traditional methods in key areas like efficiency and patient satisfaction, though research on multi-unit restorations is still limited.
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  • The study investigated the efficiency of specialized diamond rotary instruments for removing zirconia dental restorations compared to conventional diamond tools.
  • Results showed that the conventional tool cut zirconia faster and generated lower heat than the specialized tools, despite the latter being marketed for this specific purpose.
  • The study concluded that using a 2 N force with adequate water cooling is best for cutting zirconia while minimizing temperature rise and maintaining tool effectiveness.
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  • * Twenty patients received prosthetic treatments through two fully digital workflows and one mixed analog-digital workflow, with satisfaction and evaluations analyzed using ANOVA.
  • * Results showed that patients rated their satisfaction higher than dentists did across all workflows, with a strong preference for digital impressions over conventional methods, highlighting the importance of personalized approaches in dental care.
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Objective: To evaluate differences in the cellular expression of epigenetic markers and oxidative stress in periodontitis lesions between current smokers and non-smokers.

Background: Tobacco smoking is recognized as one of the major risk factors for periodontitis. However, the mechanisms by which smoking affects the progression of the disease remain to be determined.

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  • Human gingival fibroblast (HGF-1) cells are important for maintaining a barrier in the mouth, but how cement finishes impact them is unclear.
  • The study compared HGF cell behavior on two resin composite cements with different curing methods and surface treatments, finding significant effects on cell viability.
  • Results showed that the oxygen inhibition layer on cement surfaces decreased HGF cell viability, while removing it improved viability but increased surface roughness.
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Background: The objective was to determine the optimal connector size and position within zirconia disks for implant-supported cantilever fixed dental prostheses (ICFDP).

Methods: Two-unit ICFDPs ( = 60) were designed for the premolar region with connector sizes of either 9 or 12 mm and positioned in the enamel or dentin layer of two different types of zirconia disks. The restorations were milled and cemented onto zirconia implants.

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Purpose: The aim of this study was to investigate the accuracy (trueness and precision) of five intraoral scanners (IOS) using a novel reference model for standardized performance evaluation.

Materials And Methods: Five IOSs (Medit i500, Omnicam, Primescan, Trios 3, Trios 4) were used to digitize the reference model, which represented a simplified full-arch situation with four abutment teeth. Each IOS was used five times by an experienced operator, resulting in 25 STL (Standard Tessellation Language) files.

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Objective: The aim of this study was to evaluate functional and esthetic clinical outcomes and patient satisfaction with narrow-diameter implants in comparison to standard-diameter implants in the anterior zone of the maxilla in a follow-up examination after 1 to 6 years.

Method And Materials: The study was designed as a retrospective cohort study investigation including 27 patients receiving a 3.3-mm diameter single implant (NDI, n = 14) or a standard-diameter 4.

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Article Synopsis
  • The review examines the current state of precision dentistry, focusing on personalized workflows in reconstructive dentistry, and discusses the disruptive potential of new technologies for the field.!
  • It highlights how advancements like artificial intelligence (AI), augmented reality (AR), and tele-dentistry can improve diagnosis, treatment planning, and patient communication in dental practices.!
  • The review concludes that while AI fosters a shift towards personalized dental care, ethical considerations and international guidelines for data management must be addressed to ensure effective and responsible implementation.!
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Objective: The purpose of this study is to compare the bonding performance and mechanical properties of two different resin composite cements using simplified adhesive bonding strategies.

Materials And Methods: Shear bond strength of two resin composite cements (an adhesive cement: Panavia V5 [PV5] and a self-adhesive cement: RelyX Universal [RUV]) to human enamel, dentin, and a variety of restorative materials (microfilled composite, composite, polymer-infiltrated ceramic, feldspar ceramic, lithium disilicate and zirconia) was measured. Thermocycle aging was performed with selected material combinations.

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Article Synopsis
  • - The study aimed to see how different surface treatments of zirconia affect biofilm formation compared to polished titanium in a lab setting and real-life conditions.
  • - Various zirconia surfaces were tested (polished, heat-treated, machined, and sandblasted), and findings showed that polished surfaces led to significantly lower biofilm growth in vitro than titanium and some treated zirconia samples.
  • - Results indicated that for in vitro biofilms, surface treatments influenced growth, while in situ, the roughness of the surfaces was more critical, suggesting polishing zirconia helps minimize biofilm formation.
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This case series retrospectively investigated the one-year surgical outcome of regenerative peri-implantitis therapy using a hydroxyapatite (HA) bone substitute material in combination with enamel matrix derivate (EMD) and collagen membrane for guided bone regeneration (GBR). Data-sheets of patients were screened to detect patients who received identical regenerative peri implantitis-therapy with surface decontamination and GBR applying HA, EMD and a collagen membrane under broad- spectrum antibiotic regime. For inclusion, information on pre- and postoperative clinical and radiographic parameters (probing pocket depth (PPD), bleeding on probing (BOP), suppuration (SUPP) and the radiological bone level (RBL)) had to be available for statistical analysis.

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