Publications by authors named "Nicola Tupone"
Article Synopsis
- Glioblastoma multiforme (GBM) releases extracellular vesicles (EVs) that can transfer aggressive traits to other cells, making the study of these vesicles crucial for understanding tumor behavior.
- * EV proteins are being investigated to find new biomarkers and targets for treatment, with proteomic studies primarily using "bottom-up" mass spectrometry on EVs from GBM cells and patient fluids.
- * Despite identifying many dysregulated proteins, clinical translation is challenging due to inconsistent EV isolation methods and proteome analysis, highlighting the need for standardized techniques and exploring protein mutations to improve GBM therapies.*
Accuracy in the evaluation of death-induced tissue degradation for thanato-chronological purposes is strictly dependent on the condition of the biological source as well as on the precision of post-mortem interval (PMI) estimation. Thus, the optimization of tissue handling and identification of sensitive post-mortem biomarkers could help establish a timeline for post-mortem events. To this aim, we investigated the proteome changes in cortex samples of 6-week-old female SAMR1 mice over a post-mortem time course.
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