Publications by authors named "Nicola Laera"
Article Synopsis
- - Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic disorder caused by mutations in the gene for type III collagen, leading to fragile blood vessels and serious complications like aneurysms or ruptures, particularly affecting medium-sized arteries.
- - Previously, vEDS was associated with a high mortality rate and an average life expectancy of around 50 years, but recent advancements in medical awareness and treatment have improved patient outcomes significantly.
- - Current treatments, particularly the use of celiprolol, a specific heart medication, have shown promise in reducing vascular incidents in vEDS patients; however, more research is needed to fully understand its benefits, and other potential therapeutic avenues are being explored for future treatment. *
Article Synopsis
- Coronary artery disease (CAD) is the top cause of death globally and is primarily caused by a buildup of atherosclerosis in coronary arteries.
- The immune system plays a complex role in CAD by initiating an inflammatory response to arterial damage, which can lead to chronic inflammation and plaque formation involving immune cells like neutrophils and lymphocytes.
- Ongoing research is focused on understanding this immune interplay and developing therapies aimed at reducing inflammation to combat atherosclerosis and its effects on heart health.
Article Synopsis
- - Cardiovascular disease is the leading cause of death globally, with atherosclerosis being the main underlying condition that affects both stable and acute cases.
- - Recent studies on acute coronary syndromes have improved patient outcomes and highlighted the need for tailored treatments based on different patterns of atherosclerotic plaque and coronary artery disease.
- - Advances in understanding metabolic factors, lipids, genetics, and non-coding RNAs offer new insights and potential targets for managing atherosclerosis and improving clinical therapies.