Publications by authors named "Nicola J Barton"
Article Synopsis
- The inflammation in osteo- and rheumatoid arthritis is driven by various inflammatory mediators, particularly cytokines and prostaglandins, which contribute to pain, swelling, and joint damage.
- A new technique for analyzing rat joint synovial fluid was developed, allowing for precise measurement of inflammatory mediators by infusing and withdrawing saline from the knee joint.
- Results showed significant increases in pro-inflammatory cytokines, confirming the technique's effectiveness in studying arthritis and providing insights into the inflammation occurring directly within the joint.
Chronic joint pain affects physical well being and can lead to severe psychological and social problems, therefore successful long-term management is highly sought-after. No current behavioural measures of pain used in pre-clinical models mimic the clinical dolorimeter, which provides an objective measure of joint hypersensitivity. In this study we aim to use a novel behavioural readout alongside an established measure to mimic the multifactorial measurements taken in the clinic.
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