Background: Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to influenza virus infection, however, how aging affects the lung tissue damage and repair has not been completely elucidated.
Methods: Aged (16-18 months old) and young (2-3 months old) mice were infected with influenza virus intratracheally.