Publications by authors named "Nicola Herold"
Article Synopsis
- - This study introduces a new high-dimensional technique to analyze human γδ T cell subsets in their natural tissue settings, overcoming previous challenges related to antibody availability and technology limitations.
- - Researchers utilized a combination of multiplexed imaging and bioinformatics to identify and characterize γδ T cells in colon and colorectal cancer samples, uncovering various microenvironments and their interactions with both immune and cancer cells.
- - Although this initial study shows the promise of this advanced technology for exploring T cell diversity and microenvironments, further research is needed to connect specific T cell characteristics and microenvironment features with important clinical factors.
Conformational change of the β2 integrin lymphocyte function-associated antigen 1 (LFA-1) is an early marker of T cell activation. A protocol using the mAb clone m24 recognizing the active, extended high-affinity conformation has been previously described for the assessment of functional CD4 and CD8 T cells in response to MHC-peptide stimulation. We investigated the applicability of the m24 mAb to detect the activation of γδ T cells in response to different soluble and immobilized stimuli.
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