Publications by authors named "Nico Schlaudraff"
Article Synopsis
- SIAH3, a member of the SIAH family in humans, is often silenced in various cancers like melanoma and lung adenocarcinoma, leading to worse survival for patients.
- Inducing SIAH3 expression can decrease cancer cell growth and trigger cell death, as it shifts cellular energy production from aerobic metabolism to glycolysis.
- SIAH3 is found in mitochondria and interacts with proteins related to mitochondrial function and other ubiquitin ligases, suggesting it plays a role as a tumor suppressor by regulating metabolism.
For several decades, cancers have demonstrably been one of the most frequent causes of death worldwide. In addition to genetic causes, cancer can also be caused by epigenetic gene modifications. Frequently, tumor suppressor genes are epigenetically inactivated due to hypermethylation of their CpG islands, actively contributing to tumorigenesis.
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