Publications by authors named "Nico R Lansu"
Article Synopsis
- Women who experienced preeclampsia have a higher risk of developing cardiovascular disease, prompting researchers to study platelets for insights into this risk.
- Platelets were isolated from asymptomatic women with a history of preeclampsia and analyzed for gene networks related to coronary artery calcium scores (CACS), revealing significant correlations and elevated gene expression levels in those with calcifications.
- The findings suggest that certain platelet RNA modules may indicate cardiovascular risk, highlighting the need for further investigation into their role in disease progression and potential genetic links to coronary artery disease.
Genome-wide association studies (GWASs) have identified many genetic risk factors for CKD. However, linking common variants to genes that are causal for CKD etiology remains challenging. By adapting self-transcribing active regulatory region sequencing, we evaluated the effect of genetic variation on DNA regulatory elements (DREs).
View Article and Find Full Text PDFTo identify novel proteins required for receptor-mediated endocytosis, we have developed an RNAi-based screening method in Drosophila S2 cells, based on uptake of a scavenger receptor ligand. Some known endocytic proteins are essential for endocytosis in this assay, including clathrin and alpha-adaptin; however, other proteins important for synaptic vesicle endocytosis are not required. In a small screen for novel endocytic proteins, we identified the Drosophila homologue of Vps35, a component of the retromer complex, involved in endosome-to-Golgi trafficking.
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