Publications by authors named "Nico Goerlitz"
Article Synopsis
- Researchers genetically modified adeno-associated virus (AAV) to include enhanced green fluorescent protein (GFP) to visualize viral trafficking and observe how AAV enters the nucleus.
- In cells infected only with AAV, viral capsids were slow to enter the nucleus, remaining mostly in the perinuclear area for several hours, while co-infection with adenovirus 5 (Ad5) significantly accelerated their nuclear entry.
- The study concludes that intact AAV capsids do not efficiently enter the nucleus, suggesting viral uncoating occurs prior to or during the entry process instead.
